Greg Isenberg

If You Want To Create Wealth In The Age of AI, Watch This

27K views · 11h ago · 22:08

In this solo episode, I lay out how I think about building an AI-proof business now that anyone can press a few buttons and spin up a company in seconds. Layoffs keep coming, people copy products pixel for pixel, and I still see more opportunity than ever. I walk through eight categories: atoms, permission, attention, timing, belonging, liquidity, unique data, and outcomes.

Topics: Atoms: Physical Businesses · Permission: Licenses, Regulation, and Partnerships · Attention: Building a Media Machine · Timing: Spotting Trends Early · Belonging: Paid Communities and IRL Events · Liquidity: Marketplaces

The $1M+ Solo Grok Bot Business (Full Course)

118K views · 2d ago · 49:32

Busy owners want their problems solved, so a GrokBot built for their industry wins over a platform they have to set up. Nick builds in three steps: research the category, design in Paper, then pick a stack and read the docs.

Topics: Bops, Custom Grok Bot Team · Dumb SaaS vs. Custom Apps · Selling AI Agent Teams · Demoing Bop · One Agent per Platform · Step 1: Research

SaaS is dead?

70K views · 6d ago · 11:13

In this solo episode, I explain why I say SaaS is dead and what I see taking its place. For 15 years, SaaS meant paying engineers to build a tool and charging per seat, and now models like Opus 5.5, GPT-6, and Argon make the tool easy to build. I walk through what I call smart SaaS: give the tool away for free, collect data and network effects, and make money by upselling AI agents and human services.

Topics: SaaS 1.0 · SaaS 2.0: The New Business Model · How to monetize SaaS 2.0 · Service is the new Software · SaaS Is Dead, Long Live SaaS · SMB vs Enterprise

$100M ARR Founder: The Next Big AI Opportunity

66K views · 1w ago · 49:21

Guest: Jon Noronha

I sit down with Jon Noronha, co-founder and chief product officer of Gamma, to break down agent harnesses and the startup openings around them. Jon explains how Gamma rebuilt its product as a creative agent this year and walks me through the roughly 20 models and 200 calls behind one finished presentation.

Topics: What Is an Agent Harness · Harnesses as the New Wrappers · Inside One Gamma Prompt · Where Vertical Harnesses Fit · Finding Your Edge · Opportunities for Harnesses

The $1,000/hour 1-person AI business

109K views · 1w ago · 44:20

Guest: James Dickerson

Get Your Complete Financial OS at I sit down with James Dickerson, the Boring Marketer, who owns Diesel Dudes, a mobile diesel repair business in Charlotte, North Carolina, and spent years running agencies for local businesses. James shows how to sell AI-built funnels to Main Street trades businesses doing $2 million to $20 million a year, starting with a Boring Funnels search that found 100 Dallas plumbers worth pitching.

Topics: Why sell AI to Main Street · James's Background · Finding and Picking a Niche · The $2M to $20M Opportunity · Plumbing and HVAC Market Size · Underserved Trades Niches

The 9 Stages of AI Agent Adoption, Explained

56K views · 2w ago · 31:13

Agents read product details, prices, shipping, and return policies, so plain-text facts on the page decide whether they pick you. Agents climb a ladder of trust from research to prepare to pay, and the whole fight happens on the pay rung.

Topics: The Three Camps · How I Define an Agent · The Ladder of Trust · Real Reasons to Block Agents · What Agents Skip · How Each Company is Playing it

Meta Muse Will Create 1,000 Millionaires

301K views · 2w ago · 24:35

Get Your Complete Financial OS at Key Points A clean list of names, needs, prices, and trust signals is an asset I own and can sell later. My four levels: mine the data, own the list, own the room, then build technology. A lean cost structure lets me charge a success fee of a few hundred dollars and keep high margins.

Topics: Meta Muse · Why this is a big opportunity · Picking a Niche, City, and Rules · Owning the asset and data · Cleaning Data You Own · Lessons From eBay

Make cool things with AI that people buy (Gemini 4 Argon)

99K views · 2w ago · 30:50

Gemini 4 Argon is LIVE, Google's most advanced AI model, try it for yourself Key Points Argon produces premium creative work once I give it reference images and a clear direction. Argon builds Shopify product customizers that export print-ready STL files. Free, focused rebuilds of boring legacy SaaS put me in front of likely buyers. Argon gets the engineering right on prompt one, and design takes a few more rounds.

Topics: What Gemini 4 Argon Does Well · Justine Moore's Apple Computer Museum · Using Argon for writing · Physical AI and Vibe Manufacturing · Building Boring SaaS · Commercial Cleaning Quote App

8 GitHub Repos To Go Viral and Make Money

130K views · 3w ago · 24:29

Brag Agent Reach Voice Studio PPT Master OpenRig Free Tool Grill Me Skill Impeccable Skill Key Points Posts on Reddit, X, and YouTube show tasks people still do by hand, and a small tool can fix them. Translated onboarding videos make a recurring monthly service for other companies. Grill Me logs my assumptions so I check them with a real customer before I build. Ten clients at $1,000 a month is $10,000 a month, and that cash flow funds the move from services to technology.

Topics: Brag: Launch Videos From a Link · Agent Reach for Customer Research · Voice Studio: Local AI Voice and Dubbing · PPT Master: Editable Decks From Notes · OpenRig: Coding Agents as a Team · Free Tools Skill by Corey Haynes

13 Businesses for the Age of AI

184K views · 4w ago · 25:17

In this solo episode, I walk through the 13 businesses I think are left to build in the agentic era. I believe that in a world of agents and abundance, owning the right assets puts you in a better position. For each business, I explain what it is, why it holds up in a world of agents, and one or two examples, from Othership's sauna clubs to Osmo's window-cleaning robots. This episode gives you a map of where to build next, at any age.

Topics: AI-Native Service Firms · Offline Businesses · Distribution and Organic Audiences · Proprietary Data Sets · Domain-Specific Harnesses · Robotics and Physical AI

Masterclass: How FDEs make $1M/yr deploying AI agents

121K views · 1mo ago · 53:59

Google's most advanced audio models are LIVE, try them for yourself Gemini 3.8 Live Gemini 3.5 Transcribe Gemini 3.5 Live Translate In this episode, I talk with Vas from Varick about what it takes to put AI to work inside a real company.

Topics: FDE Overview · AI Roll-Ups and Process Reengineering · The Personal Systems Analogy · Understanding a company’s process (step-by-step) · Case Study: $5B Software Company · 4 Buckets for Every Step

OpenAI DevDay: Dots, Agents & $100B Opportunities

184K views · 1mo ago · 18:56

Guest: OpenAI DevDay

I watched almost 60 minutes of Sam Altman on stage at OpenAI Dev Day 2026. Out of 20-plus launches, I pick the three or four that I think can make people billions of dollars in aggregate. I break down Dots, OpenAI's personal agent platform, plus the Decisions API, the Agents API with computer use, and Sign in with ChatGPT. I also share my four-step framework for building in this world and two business ideas I hope someone takes.

Topics: Dots, the Personal Agent Platform · OpenAI Doubles Down on Plugins · Decisions API · Agents API With Computer Use · Sign In With ChatGPT · Where should you build?

$5T opportunity: AI Roll Ups

198K views · 1mo ago · 29:50

In this solo episode, I break down the $5 trillion wave of small businesses set to change hands as their owners retire, and why AI agents make this wave a real opening for solo founders. I walk through how Thrive Holdings and General Catalyst buy accounting firms, property managers, and support centers, then run AI agents inside them to lift margins.

Topics: Why the $5 Trillion Shift Is Happening Now · Examples: Thrive Holdings& General Catalyst · The Fund Playbook · The Small-Deal Gap · The One-Person Holdco · The Folder Structure

Meta Muse AI Connectors: The App Store for AI?

160K views · 1mo ago · 26:16

Guest: Meta Muse AI Connectors

Meta has opened Muse to developers, and a connector lets Muse use your service when someone asks it for help. I look closely at the step in a request where someone needs a business that can deliver and money changes hands. With a small budget, I'd start with lead generation, because I can show a customer a sample before writing much software. I plan distribution around channels I can reach, such as creators, product-led sharing, and connected marketplaces.

Topics: How a Muse Connector Works · Startup Idea 2: Home Repair Dispatch · Startup Idea 3: Paddle Match and Court Finder · Startup Idea 4: Family Dinner Planning · How to pick an idea? · How People Find Your Connector

Take Upwork jobs, let AI do them (Astra etc). It's absurd.

122K views · 1mo ago · 48:05

Build your own AI native creative agency with Higgsfield In this solo episode, I explain why I expect a wave of one-person businesses built as AI-native service firms, and I show you how I built one. Three things matured at the same time: specialist creative models, Astra as an orchestrator that plans and repairs work, and the Higgsfield API, which puts 50+ creative models behind one key.

Topics: 3 Shifts, All at Once · The AI-Native Service Firm · Demand on Upwork and Fiverr · Human Agency vs. AI-Native Firm · Studio Operator Tour · The Six Build Prompts